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Maybe you thought Hidradenitis Suppurativa (HS) is caused by poor hygiene, being overweight, or cigarette smoking…HS is not your fault. While the exact cause is unknown, medical science has shown that HS is an immune disease. With HS, your body produces too much of a protein called TNF-alpha, this along with other proteins leads to increased inflammation, which produces abscesses that appear underneath and on the surface of your skin. HS is a chronic disease, but there are treatments available, such as Humira.